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The Next
Re-Generation
AnGelHA
Gelatin & Hyaluronic Acid Co-Matrix
Biostimulating Dermal Filler
Products intended only for professional use. Can be injected by a certified medical professional.
Gelatin & Hyaluronic Acid Co-Matrix
Biostimulating Dermal Filler
The innovative BioStimulating Dermal Filler combines 30 mg/mL of Gelatin and 20 mg/mL of Hyaluronic Acid, cross-linked to form a single co-matrix with a synergistic effect. This unique combination enhances fibroblast recruitment and proliferation, promoting the production of collagen and elastin.
Gelatin supports tissue regeneration and stimulates fibroblast activity, while Hyaluronic Acid provides hydration and volume. Designed to boost collagen and elastin production, the cross-linking ensures longer-lasting effects and sustained skin rejuvenation.
3 sessions
2-4 weeks apart
2 syringes in each session
Injection site:
cheeks ,perioral lines, lips, chin, glabella.
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- Gelatin, derived from denatured collagen, retains RGD
(Arg-Gly-Asp) motifs that promote fibroblast attachment.
- Integrins (αvβ3, α5β1) on fibroblasts recognize RGD, triggering adhesion and migration into the co-matrix.
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- HA hydrates the ECM, creating a permissive environment for fibroblast movement.
- CD44 receptor interaction triggers cytoskeletal changes, enhancing fibroblast migration and survival.
- High HA levels support fibroblast proliferation and reduce oxidative stress.
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- The interpenetrating polymer network (IPN) mimics native ECM, aiding fibroblast anchoring & spreading.
- Embedded fibroblasts secrete new collagen, elastin, and glycosaminoglycans, restoring dermal structure.
- Gradual ECM remodeling leads to sustained fibroblast activity and long-term skin rejuvenation.
The results shown below are 3 weeks after the second treatment. A notable improvement can be seen in the appearance of the wrinkles, their depth, and the skin texture, without a significant increase in volume.
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When we age Elastin and Collagen fibers degradeAnGelHa promotes recruitment and aggregation of fibroblasts into clusters, leading to the natural production of endogenous collagen and elastin.
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Naturally embedded within collagen but exposed only upon denaturation into gelatin
Gelatin contains RGD sequence, that promotes cell adhesion and Fibroblast recruitment
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